Asymmetric N-(3, 3-diphenylpropyl) aminoalkyl esters of 4-aryl-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylic acids with antihypertensive activity

…, G Sironi, A Catto, A Cerri, M Zappa, G Bianchi…

文献索引：Leonardi, Amedeo; Motta, Gianni; Pennini, Renzo; Testa, Rodolfo; Sironi, Giorgio; Catto, Alberto; Cerri, Alberto; Zappa, Marco; Bianchi, Giorgio; Nardi, Dante European Journal of Medicinal Chemistry, 1998 , vol. 33, # 5 p. 399 - 420

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被引用次数: 20

摘要

A series of asymmetric 4-aryl-1, 4-dihydropyridine-3, 5-dicarboxylates characterized by the presence of a 3, 3-diphenyl-propylamino moiety in one of the ester groups were synthesized. They exhibited remarkable antihypertensive activity in spontaneously hypertensive rats as well as affinity for the 1, 4-dihydropyridines binding site labelled by 3H- nitrendipine in the calcium channel. Introduction of this bulky and lipophilic amine confers ...