Tetrahedron

Structural Modifications and Biological Evaluation of 3-Isoxazolylvinylcephalosporins

…, JE Lee, BH Kim, JH Cha, HY Kim, YS Cho, KI Choi…

文献索引：Pae, Ae Nim; Lee, Jie Eun; Kim, Bo Hyung; Cha, Joo Hwan; Kim, Hea Yeon; Cho, Yong Seo; Choi, Kyung Il; Koh, Hun Yeong; Lee, Eun; Kim, Je Hak Tetrahedron, 2000 , vol. 56, # 31 p. 5657 - 5665

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被引用次数: 10

摘要

Structural modifications and biological evaluations of 3-isoxazolylvinylcephalosporins (I) were performed. The replacement of a hydrogen atom at the 7-aminothiazole group by a chlorine resulted in an improvement of the activity against resistant Gram-positive bacterial strains including the methicillin-resistant Staphylococcus aureus (MRSA) and the ciprofloxacin-resistant Staphylococcus aureus (CRSA). The introduction of other ...