Carbohydrate research

Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells

WY Liu, HY Li, BX Zhao, DS Shin, S Lian, JY Miao

文献索引：Liu, Wei-Yong; Li, Hai-Ying; Zhao, Bao-Xiang; Shin, Dong-Soo; Lian, Song; Miao, Jun-Ying Carbohydrate Research, 2009 , vol. 344, # 11 p. 1270 - 1275

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被引用次数: 39

摘要

A series of novel ribavirin hydrazone derivatives were synthesized by the reaction of ribavirin hydrazone with benzaldehyde or acetophenone derivatives. The structures of the compounds were determined by IR, 1H NMR, and HRESIMS. Preliminary biological evaluation showed that one compound (7h) inhibits the growth of A549 cells at 20μM.

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