2-(Arylalkylamino) adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands

…, M Williams, R De Jesus, R Yokoyama…

文献索引：Hutchison, Alan J.; Williams, Michael; Jesus, Reynalda, de; Yokoyama, Rina; Oei, Howard H.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1919 - 1924

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被引用次数: 137

摘要

Nli, was oxidized with KMnO, in aqueous base under high dilution conditions to afford the carboxylic acid 5 in 74% yield. Running this reaction at higher concentrations resulted in much lower yields of the desired product. The acid 5 was converted to the corresponding acid chloride with SOClz and a catalytic amount of DMF, and the crude acid chloride reacted with methyl-, ethyl-, or cyclopropylamine to afford the amides 6a-c in good overall yields. ...