Since first launching ceftazidime to the market as a kind of pyridinium cephalosporin, many efforts have been dedicated to develop quaternary ammonium cephalosporin with broad spectrum against Gram-positive and Gram-negative microorganisms and to overcome the multidrug-resistance. 1, 2 and 3 Representative ceftadizime have a tendency to be mainly used to treat opportunistic infection with Pseudomonas aeruginosa strains, meanwhile ...
