Synthesis of methyl (5Z, 8Z, 11Z, 14Z, 17Z)??and (5Z, 8Z, 11Z, 14Z, 17E)??[18??14C] eicosapentaenoate

T Eynard, D Poullain, JM Vatèle, JP Noël…

文献索引：Eynard, Thierry; Poullain, Didier; Vatele, Jean-Michel; Noel, Jean-Pierre; Chardigny, Jean-Michel; Sebedio, Jean-Louis Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 5 p. 411 - 421

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被引用次数: 6

摘要

Abstract In order to have a better insight of the effect of the double bond geometry of EPA on its anti-aggregating properties, methyl ester of [18-14 C] EPA and of its Δ17t isomer were synthesized from a common intermediate [(3Z, 6Z, 9Z)-12, 12-diethoxydodeca-3, 6, 9-trienyl] triphenylphosphonium iodide 11 via three sequential Wittig olefination. Labelled methyl ester of EPA 16b and EPAΔ17t17b were obtained in near 10% isomeric and ...