Azetidine-derived amino acids versus proline derivatives. Alternative trends in reverse turn induction

…, MT García-López, R González-Muniz…

文献索引：Baeza, Jose Luis; Gerona-Navarro, Guillermo; De Vega, M. Jesus Perez; Garcia-Lopez, M. Teresa; Gonzalez-Muniz, Rosario; Martin-Martinez, Mercedes Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1704 - 1715

全文：HTML全文

被引用次数: 36

摘要

The influence of 2-alkyl-2-carboxyazetidines (Aze) on the 3D structure of model tetrapeptides R2CO-2-R1Aze-l-Ala-NHMe has been analyzed by molecular modeling, 1H NMR, and FT-IR studies. The conformational constraints introduced by the four-membered ring resulted in an effective way to stabilize γ-turn-like conformations in these short peptides. The conformational preferences of these Aze-containing peptides have been compared to ...