Tetrahedron

Enzyme-mediated enantioselective hydrolysis of soluble polymer-supported carboxylates

…, N Chihara, T Nakagawa, K Mizuochi, K Matsumoto

文献索引：Okudomi, Masayuki; Ageishi, Kanpei; Yamada, Tomomi; Chihara, Naoka; Nakagawa, Takuya; Mizuochi, Katsumi; Matsumoto, Kazutsugu Tetrahedron, 2010 , vol. 66, # 40 p. 8060 - 8067

全文：HTML全文

被引用次数: 7

摘要

The enzyme-mediated enantioselective hydrolysis of water-soluble polymer-supported carboxylates is disclosed. The representative monomethoxy poly (ethylene glycol)(MPEG, av MW 5000)-supported substrate was synthesized by immobilization of (±)-1-phenylethanol onto the modified MPEG (MPEG/NH2) through an carboxylate linker with a succinate spacer. For the screening of the hydrolytic enzymes, the substrate was enantioselectively ...