Chalcone inhibition of anthracycline secondary alcohol metabolite formation in rabbit and human heart cytosol

A Silvestrini, E Meucci, A Vitali, B Giardina…

文献索引：Botta, Bruno; Delle Monache, Giuliano; De Rosa, Maria Cristina; Scurria, Rosalba; Vitali, Alberto; Vinciguerra, Vittorio; Menendez, Pilar; Misiti, Domenico Heterocycles, 1996 , vol. 43, # 7 p. 1415 - 1421

全文：HTML全文

被引用次数: 14

摘要

Antineoplastic therapy with anthracyclines like doxorubicin (DOX) and daunorubicin (DNR) is limited by the possible development of a dose-related cardiomyopathy. Secondary alcohol metabolites like doxorubicinol (DOXol) and daunorubicinol (DNRol), formed by cytoplasmic