Tetrahedron letters

Immunologically driven antibodies chemical engineering: design and synthesis of a hapten aimed at nerve agent hydrolysis

F Jovic, L Louise, C Mioskowski, PY Renard

文献索引：Jovic, Florence; Louise, Ludivine; Mioskowski, Charles; Renard, Pierre-Yves Tetrahedron Letters, 2005 , vol. 46, # 40 p. 6809 - 6814

全文：HTML全文

被引用次数: 8

摘要

In this letter, we describe the design and the synthesis of an organophosphorus hapten aimed at a mixed biotechnological–chemical strategy for the mild decontamination of exceedingly toxic nerve agent VX. Hapten will be used to raise and select monoclonal antibodies (mAbs) able to bind both the nerve agent, and an oxime, derived from pyridinaldoxime, able to specifically hydrolyze its P–S bond. In order to significantly ...