Organic preparations and procedures international

A CONVENIENT PREPARATION OF 9 H-FLUORENE-9-ACETIC ACID

RR Goehring

文献索引：Goehring, R. Richard Organic Preparations and Procedures International, 1994 , vol. 26, # 4 p. 476 - 478

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被引用次数: 2

摘要

As part of a program for the synthesis of leukocyte recruitment inhibitors (leumedins)'we required substantial quantities of 9H-fluorene-9-acetic acid (3a). While 3a is commercially available, we found the price to be prohibitively high? A number of routes to 3a have been described in the literature.'These include Reformatsky reaction with fluorenone (1), 3b, c alkylation of diethyl malonate with 9-brom0lluorene,~~ alkylation of tluorene with glycolic ...