Synthesis and in vitro evaluation of 18 F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents

L Wang, W Qu, B Lieberman, K Ploessl…

文献索引：Wang, Limin; Qu, Wenchao; Lieberman, Brian; Ploessl, Karl; Kung, Hank F. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3482 - 3485

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被引用次数: 7

摘要

Three new 18F labeled fluoroalkyl tyrosine derivatives, O-(2-[18F] fluoroethyl)-α- methyltyrosine (FEMT,[18F] 2), O-(2-[18F] fluoroethyl)-2-l-azatyrosine (FEAT,[18F] 3), O-(2- [18F] fluoroethyl)-l-tyrosineamide (FETA,[18F] 4) have been synthesized and radiofluorinated with 5–34% decay-corrected yield. In vitro studies were carried out in U-138 MG human glioblastoma. Cellular uptake of new tracers was compared to clinically ...