Research and development of an efficient process for the construction of the 2, 4, 5-substituted pyridines of NK-1 receptor antagonists

PJ Harrington, D Johnston, H Moorlag…

文献索引：Organic Process Research and Development, , vol. 10, # 6 p. 1157 - 1166

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被引用次数: 5

摘要

... Organic Process Research & Development. ... Method B). We prefer to avoid the salt isolation by using Method B. A near-optimal procedure for the ... 10 We observed that stoichiometry and the presence of a sacrificial solvent are critical factors in an efficient process using sulfuric ...