8-Fluoroimidazo [1, 2-a] pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo [1, 2-a] pyrimidine in an allosteric …

AC Humphries, E Gancia, MT Gilligan…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 6 p. 1518 - 1522

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被引用次数: 69

摘要

... Bioorganic & Medicinal Chemistry Letters. ... During the course of a medicinal chemistry programme aimed at discovering novel allosteric modulators of the GABA A receptor ... Since this chemistry was first disclosed, 17 it has been established that Buchwald aminations of 3-fluoro-2 ...