Rationally designed 'dipeptoid'analogues of cholecystokinin (CCK): C-terminal structure-activity relationships of α-methyl tryptophan derivatives

…, JM Eden, M Higginbottom, DR Hill, DC Horwell…

文献索引：Boden, P. R.; Eden, J. M.; Higginbottom, M.; Hill, D. R.; Horwell, D. C.; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 47 - 61

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被引用次数: 16

摘要

Abstract This paper outlines the synthesis and C-terminal structure-activity relationships (SAR) of a series of α-methyl tryptophanylphenethylamide analogues of the neuropeptide cholecystokinin (CCK). CCK-B and CCK-A receptor binding affinities of these analogues are described and the contributions of the various side chains on the phenethylamide moiety to binding affinity are discussed. Several of the compounds prepared have CCK-B receptor ...