Development of a multigram synthesis of URB937, a peripherally restricted FAAH inhibitor

…, R Scarpelli, D Piomelli, T Bandiera

文献索引：Fiorelli, Claudio; Scarpelli, Rita; Piomelli, Daniele; Bandiera, Tiziano Organic Process Research and Development, 2013 , vol. 17, # 3 p. 359 - 367

全文：HTML全文

被引用次数: 5

摘要

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield.