Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere

MJ Fisher, U Giese, CS Harms, MD Kinnick…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 4 p. 385 - 389

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被引用次数: 14

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Removal of the Cbz group with hydrogen and palladium provided secondary amine Scheme 1 and Scheme 2, which was transformed into the target molecule Scheme 1 and Scheme 2 using chemistry similar for the preparation of ...