Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains

…, BL Mylari, HL Howes Jr, SK Figdor…

文献索引：Miller, Max W.; Mylari, Banavara L.; Howes, Harold L.; Figdor, Stanford K.; Lynch, Martin J.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1337 - 1342

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被引用次数: 12

摘要

We report further progress in exploiting our earlier discovery that the anticoccidial activity of 6-azauracil increases markedly when appropriately substituted benzyl or phenyl groups are attached at N-1. With guidance from previous structure-activity relationships and a multiple linear regression analysis, 6-azauracils containing phenyl sulfone or phenyl sulfide side chains were prepared. These prevented a broad spectrum of coccidial infections in ...