Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting …
Structural modification of the calcium-antagonist verapamil (1) by replacement of the lipophilic a-isopropylacetonitrile moiety by various heterocyclic ring systems has led to a new class of cardiovascular compounds which are characterized by a specific bradycardic activity. These agents reduce heart rate without binding to classical calcium channels or P- adrenoceptors, interacting instead specifically with structures at the sino atrial node. ...
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