Bioorganic & medicinal chemistry letters

Synthesis and evaluation of novel 1, 3, 4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent

RA Rane, SD Gutte, NU Sahu

文献索引：Rane, Rajesh A.; Gutte, Shweta D.; Sahu, Niteshkumar U. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6429 - 6432

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被引用次数: 33

摘要

In an attempt to identify new potential lead as antimicrobial agent, twenty hybrids of marine bromopyrrole alkaloids with 1, 3, 4-oxadiazole were designed based on molecular hybridization technique and synthesized. Synthesized molecules were evaluated for their antibacterial, antifungal and antitubercular activities. Hybrids 5d, 5i, 5j and 5k exhibited equivalent antibacterial activity (MIC of 1.56 μg/mL) compared with standard drug ...