Synthetic communications

A preparative scale reduction of alkyl disulfides with tributyl phosphine and water

JT Ayers, SR Anderson

文献索引：Ayers, Joshua T.; Anderson, Shelby R. Synthetic Communications, 1999 , vol. 29, # 3 p. 351 - 358

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被引用次数: 22

摘要

Abstract A series of alkyl disulfides has been shown to be reduced by tributyl phosphine at room temperature. The resulting thiols were then acylated in the same pot and isolated in good yields. This sequence is convenient and is a practical option for the preparation of gram quantities of thiol or thioester from the corresponding disulfide.