Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents

…, D Bansal, K Bajaj, S Sharma, VK Srivastava

文献索引：Kumar, Ashok; Bansal, Deepti; Bajaj, Kiran; Sharma, Shalabh; Archana; Srivastava Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5281 - 5291

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被引用次数: 27

摘要

Diazotization of N-benzylidene anthranilic acids 1a–1n at pH 9 yielded N-[α-(phenylazo) benzylidene] anthranilic acids 2a–2n and at pH 3 yielded N-benzylidene-5-(phenylazo) anthranilic acids 3a–3n. When compounds 3a–3n were treated with thioglycolic/thiolactic acid in the presence of anhydrous ZnCl2, 2-(4-oxo-2-phenylthiazolidin-3-yl)-5-(phenylazo) benzoic acids 4a–4n were afforded. The newly synthesized compounds were screened ...