1-Aryl-6, 7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents

…, FS Menniti, G Ferreri, G De Sarro, C De Micheli

文献索引：Zappala, Maria; Grasso, Silvana; Micale, Nicola; Zuccala, Giuseppe; Menniti, Frank S.; Ferreri, Guido; De Sarro, Giovambattista; De Micheli, Carlo Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4427 - 4430

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被引用次数: 48

摘要

A set of novel 1-aryl-6, 7-methylenedioxy-3H-quinazolin-4-(thi) ones (3a–f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2, 3-benzodiazepine site of the AMPA receptor complex has been assayed.