Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1 H-pyrazol-3-yloxy] …

JL Díaz, R Cuberes, J Berrocal…

文献索引：Doria, G.; Passarotti, C.; Sala, R.; Magrini, R.; Sberze, P.; et al. Farmaco, Edizione Scientifica, 1986 , vol. 41, # 6 p. 417 - 429

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被引用次数: 41

摘要

... 4 h; (ii) NHR 4 R 5 , K 2 CO 3 , NaI, DMF, 100 °C, 8 h; (g) (i) P ... triethylamine, rt, 18 h; (ii) 4-(2-chloroethyl)morpholine hydrochloride, K 2 CO 3 , KI, DMF, 95 °C; (iii) EtOH ... of the new series was performed taking into account the known pharmacophoric features of σ 1 R. As recently ...