Evaluation of some Mannich bases of cycloalkanones and related compounds for cytotoxic activity

JR Dimmock, KK Sidhu, M Chen, RS Reid…

文献索引：Dimmock, JR; Sidhu, KK; Chen, M; Reid, RS; Allen, TM; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 4 p. 313 - 322

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被引用次数: 77

摘要

Abstract A number of Mannich bases of cycloalkanones and related quaternary ammonium compounds were prepared for cytotoxic evaluation in order to examine the theory that sequential release of alkylating agents produces increased bioactivity compared to related compounds containing only 1 potential alkylating site. Many of the compounds had significant activity against murine L1210 cells and various human tumours. Some ...