2??Aza??2′??deoxyadenosine: Synthesis, Base??Pairing Selectivity, and Stacking Properties of Oligonucleotides

…, E Schweinberger, Z Kazimierczuk…

文献索引：Sugiyama, Tamizi; Schweinberger, Enno; Kazimierczuk, Zygmunt; Ramzaeva, Natalya; Rosemeyer, Helmut; Seela, Frank Chemistry - A European Journal, 2000 , vol. 6, # 2 p. 369 - 378

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被引用次数: 28

摘要

Abstract The artificial base 2-aza-2′-deoxyadenosine (see figure) forms a strong and selective purine-purine base pair with 2′-deoxyguanosine. As a dangling nucleotide, 2-aza- 2′-deoxyadenosine stabilizes DNA duplexes less than 2′-deoxyadenosine, while 7- deaza-2′-deoxyadenosine, a more hydrophobic base, has the greatest duplex-stabilizing effect.