Gold (I)-Catalyzed Tandem Reactions Initiated by Hydroamination of Alkynyl Carbamates: Application to the Synthesis of Nitidine

…, AL Girard, Y Yasui, Y Takemoto

文献索引：Enomoto, Taro; Girard, Anne-Lise; Yasui, Yoshizumi; Takemoto, Yoshiji Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9158 - 9164

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被引用次数: 61

摘要

As a convenient and direct synthesis of 1, 2-dihydroisoquinolines, the gold (I)-catalyzed intramolecular hydroamination of (2-alkynyl) benzyl carbamates has been developed. The reaction with cationic gold (I) complex [AuCl (PPh3)/AgNTf2] proceeded at room temperature, giving the desired 6-endo adducts. The addition of alcohol efficiently promoted the reaction, and the amount of the catalyst could be reduced to 1 mol%. However, the ...