Tetrahedron letters

Total ssynthesis of (±) thiolactomycin

CLJ Wang, JM Salvino

文献索引：Wang, Chia-Lin J.; Salvino, J. M. Tetrahedron Letters, 1984 , vol. 25, # 46 p. 5243 - 5246

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被引用次数: 73

摘要

Abstract We have completed the first total synthesis of (±)-thiolactomycin by a five-step procedure in 10% overall yield starting from ketoester 6. The key step involves addition of dianion 3 to 3-ethoxy-2-methyl-2-propenal. The resulting aldehyde 11 was then converted into (±)-thiolactomycin. Full-size image (3 K)