Summary The synthesis of twenty-seven new metanilamides, three new orthanilamides, and seventeen variously substituted 2-phenylsulfonamidopyrimidines has been described. 2. The antimalarial activities of these compounds in avian malaria have been reported and discussed with respect to their structure. 3. Among the metanilamides studied, a majority of the N1-heterocyclic compounds showed antimalarial activity; other types of metanilamides ...