Synthetic Communications

A SIMPLE METHOD FOR THE SYNTHESIS OF 2-AMINO-1-(4′-METHOXYPHENYL)-PROPANE

HB Mereyala, SR Koduru

文献索引：Mereyala; Koduru Synthetic Communications, 2001 , vol. 31, # 19 p. 3005 - 3010

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被引用次数: 2

摘要

Synthesis of 2-amino-1-(4′-methoxyphenyl)-propane (II) starting from p-anisaldehyde (1) in 67% overall yield is described. Key reactions involved Horner–Wadswoth–Emmons olefination of 1 to form the ester 2 and Hoffmann degradation of amide 5 to obtain the amine