Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1, 3-thiazole analogs

…, SM El-Messery, FAM Al-Omary, HI El-Subbagh

文献索引：Hassan, Ghada S.; El-Messery, Shahenda M.; Al-Omary, Fatmah A.M.; El-Subbagh, Hussein I. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6318 - 6323

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被引用次数: 25

摘要

A novel series of 2-acetamido-or 2-propanamido-4-(4-substituted phenyl)-1, 3-thiazoles (11– 34) was designed and synthesized. Compounds were subjected to National Cancer Institute (NCI) in vitro assessment for their antitumor activity, at a single dose of 10μM. Most of the investigated compounds exhibited broad-spectrum antitumor activity. Compounds 19 and 28 believed to be the most active members in this study, with MG-MID GI50, TGI, and LC50 ...