30-33 iodide, ll the reaction with methyl trifluoromethanesulfonate, at 60 OC, was sluggish and the pyridinyl nucleus underwent partial quaternization. It was possible to carry out methylation of 1 by prolonged heating with methyl iodide in a sealed tube (method E), but the yield was moderate. For tertiary benzamides 30-33, an alternative synthesis was achieved by benzoylation of the secondary amines 27, 28, as outlined in Scheme I1 ( ...
