Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-(1H-tetrazol-5-yl) benzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5- …

RE Ford, P Knowles, E Lunt, SM Marshall…

文献索引：Ford; Knowles; Lunt; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 538 - 549

被引用次数: 99

摘要

The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N42-hydroxyphenyl)-lH-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties ...

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~30%

70977-85-4

1-(3-氨基-5-溴-2-羟...

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~48%

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~37%

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~66%

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~64%

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~89%

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~25%

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~56%

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~66%

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Solid-phase synthesis of new saphenamycin analogues with ant...

[Laursen, Jane B.; De Visser, Peter C.; Nielsen, Henrik K.; Jensen, Knud J.; Nielsen, John Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 171 - 175]