Materials and Methods Preparation of Materials: PoIythia~ ide-2-C~~-methyl was prepared: Sodium hydride (92.8 mg., 2.0 mmoles) was added to a solution of 3, 4-dihydro-&chloro-7- sulfamyl-3-(2, 2, 2-trifluoroethylthiomethyl)-1, 2, 4-benzothiadiazine-1, l-didioxide*(860. 1 mg., 2.0 mmoles) in dry dimethylacetamide (20 ml.). An aliquot of the solution (2.0 ml., 0.2 mmole) was removed and transferred to a vacuum apparatus; methyl iodide-C* 4 (29 mg., ...
