Synthesis and antineoplastic evaluations of 5, 8-bis [(aminoalkyl) amino]-1-azaanthracene-9, 10-diones

…, JJ Landi Jr, MP Hacker, JJ McCormack

文献索引：Krapcho; Landi Jr.; Hacker; McCormack Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1124 - 1126

全文：HTML全文

被引用次数: 31

摘要

Several 5, 8-bis [(aminoalkyl) amino]-l-azaanthracene-9, 10-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Comparisons are made to the corresponding carbocyclic analogues. One of the aza analogues showed modest in vivo activity.