Tetraazamacrocycles such as 1,4,8,11-tetraazacyclotetradecane (cyclam) have a long history in synthetic inorganic chemistry and a burgeoning significance in medicinal chemistry. 1,2 Selective derivatization of the secondary amines in cyclam is a key step in the development of new ligands for transition metals and new bioactive agents alike. 3 Statistical methods using large excesses of cyclam in conjunction with yield-limiting quantities of electrophiles have been used to ...
