Synthesis and Muscarinic Activity of a Series of Quinolines and Naphthalenes with a 1-Azabicyclo (3.3. 0) octane Moiety.

…, T Usui, M Oka, T SUzuki, T KATAOKA

文献索引：Suzuki, Tomoo; Usui, Toshinao; Oka, Mitsuru; Suzuki, Tsunemasa; Kataoka, Tadashi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1265 - 1273

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被引用次数: 16

摘要

In order to discover a medicine effective against Alzheimer's disease, we synthesized a series of quinoline derivatives having a characteristic 1-azabicyclo [3.3. 0] octane amine ring, and performed pharmacological evaluation of them. Acetylcholine esterase inhibitory activities of these derivatives were unexpectedly weak. Tests for central nervous muscarinic cholinergic receptor binding affinity indicated that these compounds had higher affinities ...