Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization

L Zhao, Y Wang, D Cao, T Chen, Q Wang…

文献索引：Xiang, Zheng; Wang, Lei Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6367 - 6371

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被引用次数: 12

摘要

The signal transduction of acetylated histone can be processed through a recognition module, bromodomain. Several inhibitors targeting BRD4, one of the bromodomain members, are in clinical trials as anticancer drugs. Hereby, we report our efforts on discovery