Synthesis, characterization and in vitro antimicrobial activity of novel 2-thioxo-4-thiazolidinones and 4, 4′-bis (2-thioxo-4-thiazolidinone-3-yl) diphenylsulfones
…, AA El-Maghraby, MTA El-Rahman, MHM Helal
文献索引：El-Gaby, Mohamed S.A.; El-Hag Ali, Gameel A.M.; El-Maghraby, Ahmed A.; Abd El-Rahman, Mohamed T.; Helal, Mohamed H.M. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4148 - 4152
2-Thioxo-4-thiazolidinones (3a, b) were achieved by cyclocondensation of isothiocyanatosulfonamides (1a, b) with sulfanylacetic acid at reflux temperature in dioxane in the presence of triethylamine. Compound (3a) was exploited to synthesize the versatile hitherto unknown 2-thioxo-4-thiazolidinones (5–10) via its reaction with some electrophiles. Cyclization of 4, 4′-diisothiocyanate diphenylsulfone (11) with sulfanylacetic acid ...
