Chemistry Letters

CESIUM FLUORIDE PROMOTES SYNTHESIS OF RIBOOLIGONUCLEOTIDES VIA PHOSPHOTRIESTER APPROACH

H Takaku, T Nomoto, M Murata, T Hata

文献索引：Takaku, Hiroshi; Nomoto, Tadaaki; Murata, Mitsuho; Hata, Tsujiaki Chemistry Letters, 1980 , p. 1419 - 1422

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被引用次数: 8

摘要

In the presence of cesium fluoride, the reactions of a fully protected 5′-O-dimethoxytrityl- 2′-O-tetrahydropyranyl-N-acylnucleoside 3′-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates with 5′-hydroxyl nucleosides proceeded rapidly under mild conditions to afford the corresponding ribodinucleoside monophosphates in good yields.