The Synthesis of N-Benzylthieno [3, 2-b] pyrrole1

AD Josey, RJ Tuite, HR Snyder

文献索引：Josey,A.D. et al. Journal of the American Chemical Society, 1960 , vol. 82, p. 1597 - 1599

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被引用次数: 11

摘要

N-Benzylthieno [3, 2-b] pyrrole (11) has been synthesized in four steps from N-benzylpyrrole in 19% over-all yield; I1 and its precursors are shown to be markedly more stable than the des-benzyl analog I and its precursors. An isomer of 11, formed as a by-product in the polyphosphoric acid cyclization of 3-(I-benzylpyrroly1thio)-acetic acid, is shown by spectral analysis to be 6-benzyl-2H, 3H-thieno [3, 2-b] pyrrol-3-one (VIIa). Similar spectral ...