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Structure-activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. I. Aryl substitutions and chloride variations

…, RD Conklin, LH Nowakowski, G Kaugars

文献索引:Rector, Douglas L.; Folz, S. D.; Conklin, R. D.; Nowakowski, L. H.; Kaugars, Girts Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 532 - 538

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被引用次数: 17

摘要

Results 2a-zz Chemistry. Synthesis of the benzoyl chloride phenylhydrazone 1 was accomplished by either chlorinating the benzaldehyde phenylhydrazone (Scheme I, method A; see preparation of lss as an example) or reacting the benzhydrazide with phosphorus pentachloride (method B, see preparation of la as an example). The chemistry and characterization data for series 1 have been reported! The acetophenone ...