Synthesis of Aromatic Analogs of 8 (S)??HETE and Their Biological Evaluation as Activators of the PPAR Nuclear Receptors

…, V Audinot??Bouchez, J Boutin, P Renard…

文献索引：Caijo, Frederic; Mosset, Paul; Gree, Rene; Audinot-Bouchez, Valerie; Boutin, Jean; Renard, Pierre; Caignard, Daniel-Henri; Dacquet, Catherine European Journal of Organic Chemistry, 2006 , # 9 p. 2181 - 2196

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被引用次数: 4

摘要

Abstract A new family of 8-HETE analogs has been synthesized as dual PPAR α and γ agonists. A versatile strategy has been developed to allow modulations not only around the aromatic core but also on the side chains of these analogs. The affinity of these compounds towards the PPARα and PPARγ receptors is reported, together with their transactivation percentage. The derivatives having a propargylic type side chain gave the most promising ...