Journal of medicinal chemistry

The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells

JC Stowell, RI Huot, L Van Voast

文献索引：Stowell, John C.; Huot, Rachel I.; Voast, Lainie Van Journal of Medicinal Chemistry, 1995 , vol. 38, # 8 p. 1411 - 1413

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被引用次数: 56

摘要

We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.