Tetrahedron: Asymmetry

An enantioselective synthesis of (R)-4-piperidinylglycine

WC Shieh, S Xue, N Reel, R Wu, J Fitt, O Repič

文献索引：Shieh, Wen-Chung; Xue, Song; Reel, Noela; Wu, Raeann; Fitt, John; Repic, Oljan Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2421 - 2425

全文：HTML全文

被引用次数: 15

摘要

An efficient process for the synthesis of (R)-Nt-Boc-4-piperidinylglycine 8a, an unnatural amino acid, via enantioselective rhodium-catalyzed hydrogenation of the Cbz-enamide 5a is described. Subsequent deprotection of 8a affords unprotected (R)-4-piperidinylglycine 9 in good yield.