Synlett

A method for selective N-Boc deprotection on Wang resin

HS Trivedi, M Anson, PG Steel, J Worley

文献索引：Trivedi; Anson; Steel; Worley Synlett, 2001 , # 12 p. 1932 - 1934

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被引用次数: 7

摘要

Abstract: A simple, inexpensive and efficient method for the selective cleavage of N-Boc protecting group under acidic conditions on high load Wang resin is described. This method employs the use of concd sulfuric acid in 1, 4-dioxan and provides an efficient process for the complete Boc deprotection with minimal loss of substrate through cleavage from resin. Key words: solid phase synthesis, selective N-Boc cleavage, high load Wang resin