Rhodium-phosphoramidite catalyzed alkene hydroacylation: mechanism and octaketide natural product synthesis

M von Delius, CM Le, VM Dong

文献索引：Von Delius, Max; Le, Christine M.; Dong, Vy M. Journal of the American Chemical Society, 2012 , vol. 134, # 36 p. 15022 - 15032

全文：HTML全文

被引用次数: 56

摘要

We describe a method that allows salicylaldehyde derivatives to be coupled with a wide range of unactivated alkenes at catalyst loadings as low as 2 mol%. A chiral phosphoramidite ligand and the precise stoichiometry of heterogeneous base are key for high catalytic activity and linear regioselectivity. This protocol was applied in the atom-and step-economical synthesis of eight biologically active octaketide natural products, ...