Based on the mathematical (QSAR) predictions for 1-arylcycloalkyl-1-penicillins, we may expect that introduction of substituents such as F, Cl, and OH into the aromatic nucleus of these compounds may lead to derivatives possessing lower toxicity and higher acid resistance [1, 2]. Previously [3], we synthesized semisynthetic penicillins and cephalosporins with Cl and Br substituents in ortho, meta, and para positions of the aromatic ring; the ...
