7-Substituted-pyrrolo [3, 2-d] pyrimidine-2, 4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for …

…, G Saponaro, MA Tabrizi, S Baraldi, P Pedretti…

文献索引：Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1690 - 1698

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被引用次数: 14

摘要

The transient receptor potential ankyrin 1 (TRPA1) channel is activated by a series of by- products of oxidative/nitrative stress, produced under inflammatory conditions or in the case of tissue damage, thus generating inflammatory and neuropathic pain and neurogenic inflammatory responses. These findings have identified TRPA1 as an emerging opportunity for the design and synthesis of selective inhibitors as potential analgesic and ...