Convenient synthesis of acetaminophen analogues containing α-amino acids and fatty acids via their mixed carbonic carboxylic anhydrides in aqueous organic …

…, R Kawashima, T Ishiki, A Matsumoto, A Nakaniwa…

文献索引：Jung, Seunghee; Tsukuda, Yuki; Kawashima, Rie; Ishiki, Takumi; Matsumoto, Ayaka; Nakaniwa, Aya; Takagi, Miho; Noguchi, Takuya; Imai, Nobuyuki Tetrahedron Letters, 2013 , vol. 54, # 42 p. 5718 - 5720

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被引用次数: 5

摘要

We have recently reported convenient syntheses of dipeptides and primary amides via mixed carbonic carboxylic anhydrides. 1 In these reports, we have showed that primary amines and ammonia work as an active nucleophile on the reaction of mixed carbonic carboxylic anhydrides in aqueous organic solvent. Aniline derivatives are less active than ammonia as a nucleophile, so it is very exciting to examine the reactivity of aniline derivatives on the ...